The HLA System and Immunological Defence against Cancer: A Review

Foetal defence against cancer: a hypothesis

It was once believed that the placenta blocks direct cell transfer between the mother and the foetus, that is, until the discovery of the maternal and foetal microchimerism which proved the existence of cell trafficking during pregnancy [1, 2]. It has been reported that 100% of the pregnant women at 36th week carry foetal cells in their circulation, the prevalence of which decreases, by 22–75%,...

A brief review of the HLA system.

Roles of Renin-Angiotensin System in the Regulation of Prostate Cancer Bone Metastasis: A Critical Review

Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption, and from the anti-tumor immune response. ...

Evidence against HLA and immunological dependence of disease outbreak in SLE. Immunological characterisation of identical twins clinically discordant for SLE.

Identical female twins clinically discordant for 20 years for SLE were studied. Their HLA-haplotype was A1,28; B8w6,w35; Cw3,w7; Dr3,4. Both twins had a raised erythrocyte sedimentation rate, autoantibodies, and circulating immune complexes. The diseases sibling had a reversed OKT4/OKT8 ratio (0.43), decreased helper T cell number, defective pokeweed mitogen (PWM) induced plasma cell differenti...

the investigation of the relationship between type a and type b personalities and quality of translation

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